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ZIF nano-dagger coated gauze for antibiotic-free wound dressing

Author:
YuanThese two authors contributed equally to this work., Yuan, Wu, Hong, Lu, Hongfang, Zheng, Yiran, Ying, Jackie Y., Zhang, Yugen
Source:
Chemical communications 2019 v.55 no.5 pp. 699-702
ISSN:
1364-548X
Subject:
Escherichia coli, Gram-negative bacteria, Staphylococcus aureus, antimicrobial properties, biocompatibility, chemical reactions, coatings, cytotoxicity, hemolysis, mice, models, nanosilver, patients, silver, tissue repair
Abstract:
Nano-dagger coated gauze was bactericidal against both Gram-positive and Gram-negative bacteria, with log reduction >7 for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available Ag gauze, the ZIF-L nano-dagger coated gauze was more biocompatible with a lower haemolytic activity, less cytotoxicity and improved wound healing performance. Animal studies showed that the ZIF-L coated gauze can effectively kill bacteria in a S. aureus wound infection model in mice. This novel nano-dagger coated gauze offers an effective and safe alternative for patients to protect against wound infections. This study demonstrates the first application of a MOF coating as an antibiotic-free wound dressing with potent antimicrobial activity and improved biocompatibility.
Agid:
6269183