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Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

Author:
ter Meer, Marja, Dillion, Ross, Nielsen, Signe Maria, Walther, Raoul, Meyer, Rikke L., Daamen, Willeke F., van den Heuvel, Lambertus P., van der Vliet, J. Adam, Lomme, Roger M. L. M., Hoogeveen, Yvonne L., Schultze Kool, Leo J., Schaffer, Jeremy E., Zelikin, Alexander N.
Source:
Chemical communications 2019 v.55 no.4 pp. 443-446
ISSN:
1364-548X
Subject:
antibiotics, bacterial growth, fluoroquinolones, glycosidic linkages, hydrolysis
Abstract:
Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.
Agid:
6269207