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Fe₃O₄–ZIF-8 assemblies as pH and glutathione responsive T₂–T₁ switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

Author:
LinThese authors contributed equally to this work., Jiaomin, Xin, Pengyan, An, Lu, Xu, Yanjun, Tao, Cheng, Tian, Qiwei, Zhou, Zhiguo, Hu, Bing, Yang, Shiping
Source:
Chemical communications 2019 v.55 no.4 pp. 478-481
ISSN:
1364-548X
Subject:
chemical reactions, glutathione, image analysis, iron oxides, liver, magnetic resonance imaging, mice, neoplasms, pH, tissues
Abstract:
A small Fe₃O₄ nanoparticles-based T₁ contrast agent was assembled into a pH- and glutathione-responsive T₂–T₁ switching contrast agent, Fe₃O₄–ZIF-8. In vivo T₁-weighted images of mice showed that Fe₃O₄–ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.
Agid:
6269231