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Iridium and a Brønsted acid cooperatively catalyzed chemodivergent and stereoselective reactions of vinyl benzoxazinones with azlactones

Author:
Sun, Meng, Wan, Xiao, Zhou, Si-Jia, Mei, Guang-Jian, Shi, Feng
Source:
Chemical communications 2019 v.55 no.9 pp. 1283-1286
ISSN:
1364-548X
Subject:
Bronsted acids, benzoxazinoids, catalytic activity, cycloaddition reactions, iridium, stereoselectivity
Abstract:
Under cooperative catalysis of iridium and a Brønsted acid, different C4-substituted azlactones react with vinyl benzoxazinones via a formal [4+2] cycloaddition or substitution reaction in a chemo- and stereoselective mode. Furthermore, the catalytic asymmetric version of the formal [4+2] cycloaddition established cooperative catalysis of iridium and a chiral thiourea-tertiary amine.
Agid:
6269232