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Enzyme-like substrate-selectivity in C–H oxidation enabled by recognition

Author:
Olivo, Giorgio, Capocasa, Giorgio, Lanzalunga, Osvaldo, Di Stefano, Stefano, Costas, Miquel
Source:
Chemical communications 2019 v.55 no.7 pp. 917-920
ISSN:
1364-548X
Subject:
catalysts, chemical bonding, chemical compounds, enzymes, oxidation
Abstract:
Substrate-selectivity stemming from recognition is a key feature of enzymes that has been seldom observed in artificial catalysts. Herein, we report a recognition-driven, substrate-selective C–H oxidation that inverts the intrinsic reactivity of the competing C–H bonds. Analysis of this selectivity highlights an unexpectedly high reactivity enhancement imparted by intramolecularity.
Agid:
6269276