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Dramatic enhancement in pH sensitivity and signal intensity through ligand modification of a dicobalt PARACEST probe
- Thorarinsdottir, Agnes E., Harris, T. David
- Chemical communications 2019 v.55 no.6 pp. 794-797
- chemical reactions, ligands, pH
- The employment of an ancillary amine-substituted bisphosphonate ligand affords a dicobalt complex able to quantitate pH with a remarkably high sensitivity of 8.8(5) pH unit⁻¹ at 37 °C through a ratiometric paramagnetic chemical exchange saturation transfer (PARACEST) approach, where the different pH dependences of amine and amide CEST peak intensities are utilized.