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Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery

Author:
Zhang, Yu-Hui, Zhang, Ying-Ming, Yu, Jie, Wang, Jie, Liu, Yu
Source:
Chemical communications 2019 v.55 no.8 pp. 1164-1167
ISSN:
1364-548X
Subject:
antineoplastic agents, chemical compounds, chemical reactions, cytotoxicity, hyaluronic acid, neoplasm cells, neoplasms, pH
Abstract:
A pH-responsive and targeted polysaccharide conjugate was fabricated from the boronate linkage of N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid with anticancer drug bortezomib, which could exhibit targeted drug release behaviors at acidic pH and possess lower cytotoxicity and a higher inhibition effect toward cancer cells.
Agid:
6269301