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Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk
- Mukherjee, R., van de. KaaPresent address: The division Internal Medicine and Dermatology, at the department Nephrology and Hypertension, University Medical Center Utrecht, The Netherlands., M., Garssen, J., Pieters, R. J., Kraneveld, A. D., Willemsen, L. E. M.
- Food & function 2019 v.10 no.1 pp. 33-37
- Bifidobacterium, DNA, coculture, epithelium, functional foods, galectins, immunomodulators, interferon-gamma, interleukin-10, lactulose, models, oligodeoxyribonucleotides, prebiotics
- Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.