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Biodegradable Polymer-Coated Multifunctional Graphene Quantum Dots for Light-Triggered Synergetic Therapy of Pancreatic Cancer

Yang, Chengbin, Chan, Kok Ken, Xu, Gaixia, Yin, Mingjie, Lin, Guimiao, Wang, Xiaomei, Lin, Wei-Jen, Birowosuto, Muhammad Danang, Zeng, Shuwen, Ogi, Takashi, Okuyama, Kikuo, Permatasari, Fitri Aulia, Iskandar, Ferry, Chen, Chih-Kuang, Yong, Ken-Tye
ACS applied materials & interfaces 2018 v.11 no.3 pp. 2768-2781
antineoplastic activity, biodegradability, doxorubicin, graphene, heat, in vivo studies, nanocarriers, pancreatic neoplasms, polyesters, quantum dots, small interfering RNA
In this work, we reported the synthesis of an engineered novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer (MiaPaCa-2 cells) therapy applications. Such a nanocarrier was utilized to co-load doxorubicin (DOX) and small interfering ribonucleic acid (siRNA), resulting in the formation of GQD/DOX/BCPV/siRNA nanocomplexes. The resulting nanocomplexes have demonstrated high stability in physiologically mimicking media, excellent K-ras downregulation activity, and effective bioactivity inhibition for MiaPaCa-2 cells. More importantly, laser light was used to generate heat for the nanocomplexes via the photothermal effect to damage the cells, which was further employed to trigger the release of payloads from the nanocomplexes. Such triggered release function greatly enhanced the anticancer activity of the nanocomplexes. Preliminary colony formation study also suggested that GQD/DOX/BCPV/siRNA nanocomplexes are qualified carrier candidates in subsequent in vivo tests.