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Lowering Effects of n-3 Fatty Acid Supplements on Blood Pressure by Reducing Plasma Angiotensin II in Inner Mongolia Hypertensive Patients: A Double-Blind Randomized Controlled Trial

Yang, Bo, Shi, Lin, Wang, Ai-min, Shi, Mei-qi, Li, Zi-hao, Zhao, Feng, Guo, Xiao-juan, Li, Duo
Journal of agricultural and food chemistry 2018 v.67 no.1 pp. 184-192
adults, alpha-linolenic acid, angiotensin II, blood pressure, corn oil, docosahexaenoic acid, eicosapentaenoic acid, fish oils, linseed oil, nitric oxide, omega-3 fatty acids, oxygen, patients, China
Whether n-3 fatty acid (FA) has hypotensive actions among Chinese adults remains inconclusive. Hypertensive patients from Inner Mongolia, China (n = 126) were recruited to a double-blind, randomized controlled trial. We investigated the effects of n-3 FA supplements on blood pressure (BP, mm Hg), plasma concentrations of angiotensin II (Ang II, pg/mL), and nitric oxygen (NO, μmol/L), using fish oil (n = 41, 4 capsules/day, equivalent to 2 g of eicosapentaenoic acid plus docosahexaenoic acid) and flaxseed oil (n = 42, 4 capsules/day, equivalent to 2.5 g of α-linolenic acid). Comparing to the control group (corn oil, n = 43), the mean systolic BP (−4.52 ± 9.28 vs −1.51 ± 9.23, P = 0.040) and the plasma Ang II levels (−12.68 ± 10.87 vs −4.93 ± 9.08, P = 0.023) were significantly lowered in the fish oil group, whereas diastolic BP (P = 0.285) and plasma NO levels (P = 0.220) were not. Such findings suggest that marine-based n-3 FA has a hypotensive efficacy in Chinese hypertensive patients possibly through inhibiting Ang II-dependent vasoconstrictions.