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Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Author:
Mikusek, Jiri, Nugent, Jeremy, Lan, Ping, Banwell, Martin G.
Source:
Journal of natural products 2018 v.82 no.1 pp. 96-100
ISSN:
1520-6025
Subject:
edema, indomethacin, nonsteroidal anti-inflammatory agents, synthesis
Abstract:
A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.
Agid:
6271408