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A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of o-Chloro Benzoates by KCl, Arynes, CO₂, and Chloroalkanes
- Jiang, Huanfeng, Zhang, Yu, Xiong, Wenfang, Cen, Jinghe, Wang, Lu, Cheng, Ruixiang, Qi, Chaorong, Wu, Wanqing
- Organic letters 2018 v.21 no.2 pp. 345-349
- benzoates, carbon dioxide, chemical reactions, chemical structure, potassium chloride
- A transition-metal-free three-phase four-component coupling reaction (3P-4CR) involving KCl, arynes, chloroalkanes and CO₂ has been reported for the first time, enabling the incorporation of both chloro and CO₂ into an aryne simultaneously. The reactions for the synthesis of different types of o-chloro benzoates can be selectively modulated by the chloroalkane utilized. The corresponding products can be alternatively transformed for postsynthetic functionalizations conveniently.