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Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering
- Chen, Tingting, Zhou, Yiyao, Lu, Yinghua, Zhang, Haoran
- Biotechnology letters 2019 v.41 no.1 pp. 27-34
- biochemical pathways, biosynthesis, coculture, engineering, fungi
- Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.