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Effects of fermented Sorghum bicolor L. Moench extract on inflammation and thickness in a vascular cell and atherosclerotic mice model

Author:
Ham, Young Min, Song, Hae Seong, Kwon, Jeong Eun, Jeon, Hyelin, Baek, Hyun Jin, Kim, Chang Won, Yoon, Weon-Jong, Choung, Eui Su, Kang, Se Chan
Source:
Natural medicines 2019 v.73 no.1 pp. 34-46
ISSN:
1340-3443
Subject:
Aspergillus oryzae, Sorghum bicolor, animal models, anti-inflammatory activity, antioxidant activity, atherosclerosis, blood circulation, blood lipids, blood vessels, chemical analysis, coronary disease, droplets, ethanol, heme oxygenase (biliverdin-producing), high fat diet, histology, inflammation, intercellular adhesion molecule-1, lipid composition, liver, lymphocytes, monocytes, pathogenesis, prostaglandin synthase, protective effect, secretion, therapeutics, tumor necrosis factor-alpha, vascular cell adhesion molecules
Abstract:
Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the pathogenesis of atherosclerosis. In particular, secretion of the pro-atherogenic cytokine tumor necrosis factor-α induces expression of endothelial adhesion molecules including P-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1), which mediate attachment of circulating monocytes and lymphocytes. In this study, we examined the anti-atherosclerotic effect of sorghum, which is known to have anti-oxidant and anti-inflammatory activity. A 50% ethanol extract of Sorghum bicolor L. Moench fermented with Aspergillus oryzae NK (fSBE) was used for experiments. In vitro expression of endothelial adhesion molecules VCAM-1 and ICAM-1 and pro-inflammatory factor cyclooxygenase-2 was significantly decreased and that of the anti-atherogenic factor heme oxygenase-1 significantly increased by fSBE (P < 0.05). At the in vivo level, we examined fat droplets of liver tissue, and aortic thickness via histological analysis, and determined the blood lipid profile through chemical analysis. fSBE at a dose of 200 mg/kg significantly improved blood and vascular health (P < 0.05). Taken together, these results demonstrate that fSBE has potential as a therapeutic anti-atherosclerotic agent.
Agid:
6275516