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Caryopincaolide M, a rearranged abietane diterpenoid with new skeleton and a new iridoid from Caryopteris incana

Author:
Zhang, Cheng-Gang, Chen, Ting, Mao, Xu-Dong, Zhao, Sen-Miao, Chou, Gui-Xin
Source:
Natural medicines 2019 v.73 no.1 pp. 210-216
ISSN:
1340-3443
Subject:
Caryopteris incana, alpha-glucosidase, diterpenoids, inhibitory concentration 50, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Caryopincaolide M (1), a new rearranged abietane diterpenoid with an unusual pent-4-enoic acid group on a 6/6/5 tricyclic ring system, and 7-epi-8-dehydroxypatriscabrol (3), a new iridoid, together with 17 known compounds, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1-D and 2-D NMR, IR, and mass spectroscopic data. Compounds 1–5 were evaluated for their inhibitory activities against enzyme α-glucosidase, and the results showed that only 1 has moderate inhibitory activity against enzyme α-glucosidase with IC₅₀ at 528.3 ± 12.37 mg/L.
Agid:
6275524