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Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

Author:
Fan, Dongsheng, Li, Ting, Zheng, Zhiyuan, Zhu, Guo-Yuan, Yao, Xiaojun, Jiang, Zhi-Hong, Bai, Li-Ping
Source:
Natural medicines 2019 v.73 no.1 pp. 23-33
ISSN:
1340-3443
Subject:
Tripterygium, cell lines, electrospray ionization mass spectrometry, humans, macrolides, nuclear magnetic resonance spectroscopy, pyridine alkaloids, rheumatoid arthritis, sesquiterpenoids, spectral analysis, stems, viability
Abstract:
Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (1–9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.
Agid:
6275529