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Antiviral activity of itraconazole against type I feline coronavirus infection

Author:
Takano, Tomomi, Akiyama, Misuzu, Doki, Tomoyoshi, Hohdatsu, Tsutomu
Source:
Veterinary research 2019 v.50 no.1 pp. 5
ISSN:
1297-9716
Subject:
Feline coronavirus, antiviral agents, antiviral properties, cats, feline infectious peritonitis, fungi, itraconazole, serotypes, therapeutics
Abstract:
Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70–90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.
Agid:
6276429