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Layer‐specific myocardial function in asymptomatic cats with obstructive hypertrophic cardiomyopathy assessed using 2‐dimensional speckle‐tracking echocardiography

Suzuki, Ryohei, Mochizuki, Yohei, Yoshimatsu, Hiroki, Niina, Ayaka, Teshima, Takahiro, Matsumoto, Hirotaka, Koyama, Hidekazu
Journal of veterinary internal medicine 2019 v.33 no.1 pp. 37-45
cardiomyopathy, case-control studies, cat diseases, cats, echocardiography, myocardium
BACKGROUND: Hypertrophic cardiomyopathy (HCM), a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of layer‐specific myocardial function with 2D speckle‐tracking echocardiography in cats with asymptomatic HCM has not yet been reported. OBJECTIVES: To quantitatively measure layer‐specific myocardial function of asymptomatic cats with HCM. ANIMALS: Ten client‐owned, asymptomatic cats with obstructive HCM and 13 healthy cats. METHODS: A retrospective, case‐control study. Cats underwent assessment of layer‐specific myocardial function (whole, endocardial, and epicardial) in the longitudinal and circumferential directions by using 2D speckle‐tracking echocardiography. RESULTS: Longitudinal strains were significantly lower in cats with HCM than controls in the whole (−15.5% vs −19.1%), endocardial (−18.3% vs −21.8%), and epicardial (−13.1% vs −16.8%) layers. Circumferential strains in whole and epicardial layers also were significantly lower in cats with HCM as compared with controls (−15.0% vs −20.2% and − 4.4% vs −9.4%, respectively). However, no significant difference was found between cats with HCM and controls in the global circumferential strain in the endocardial layer (−31.2% vs −34.2%). The circumferential endocardial‐to‐epicardial strain ratio was significantly higher in cats with HCM than in controls (6.1 vs 3.5). CONCLUSIONS AND CLINICAL IMPORTANCE: Layer‐specific myocardial function assessed by 2D speckle‐tracking echocardiography differed in asymptomatic cats with obstructive HCM compared to controls despite their apparently normal systolic function, as determined by conventional echocardiography. The maintained endocardial circumferential strain and higher circumferential endocardial‐to‐epicardial strain ratio may reflect compensation for occult systolic dysfunction in cats with obstructive HCM.