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Optimisation of the microencapsulation conditions and physicochemical properties of enteric‐coated lactase microcapsules

Author:
Ahn, Sung‐Il, Kim, Augustine Yonghwi, Kwak, Hae‐Soo
Source:
International journal of dairy technology 2019 v.72 no.1 pp. 23-35
ISSN:
1364-727X
Subject:
beta-galactosidase, coatings, gastric juice, intestines, methylcellulose, microencapsulation, pH, particle size, phthalates, response surface methodology, zeta potential
Abstract:
Enteric double‐coated lactase microcapsules were developed, and the encapsulation conditions were optimised using response surface methodology. The optimum concentration of the enteric coating material was 4.85 g/100 mL, and the amount of core material was 1.85 mL. The particle size of the zein‐coated microcapsules was 2.868 μm, which was smaller than that of the other microcapsules. All microcapsules showed high zeta‐potential values between pH 6 and 8. The in vitro release rates of hydroxypropyl methyl cellulose phthalate (HPMCP)‐ and shellac‐coated microcapsules were superior to that of the zein‐coated microcapsules. Finally, the microcapsules were barely hydrolysed in simulated gastric fluid; however, almost all the microcapsules coated with HPMCP or shellac released their contents in simulated intestinal fluid within 2 h (93.23 and 97.27%, respectively).
Agid:
6279101