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A novel genomic approach to herbicide and herbicide mode of action discovery

Author:
Duke, Stephen O, Stidham, Mark A, Dayan, Franck E
Source:
Pest management science 2019 v.75 no.2 pp. 314-317
ISSN:
1526-498X
Subject:
acid tolerance, biochemical pathways, enzymes, genomics, herbicides, mechanism of action, multigene family, sesquiterpenoids
Abstract:
A herbicide with a new mode of action has not been commercialized for more than 30 years. A recent paper describes a novel genomic approach to herbicide and herbicide mode of action discovery. Analysis of a microbial gene cluster revealed that it encodes genes for both the biosynthetic pathway for production of the sesquiterpene aspterric acid and an aspterric acid‐resistant form of dihydroxy acid dehydratase (DHAD), its target enzyme. Aspterric acid is weak compared with commercial synthetic herbicides, and whether DHAD is a good herbicide target is unclear from this study. Nevertheless, this genomic approach provides a novel strategy for the discovery of herbicides with new modes action. © 2018 Society of Chemical Industry
Agid:
6279352