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Electron microscopic study of human immunodeficiency virus type 1 (HIV-1) core structure: two RNA strands in the core of mature and budding particles
- Takasaki, T., Kurane, I., Aihara, H., Ohkawa, N., Yamaguchi, J.
- Archives of virology 1997 v.142 no.2 pp. 375-382
- Human immunodeficiency virus, RNA, photographs, transmission electron microscopy
- The basic structure of human immunodeficiency virus type 1 (HIV-1) has been investigated morphologically; however, the internal structure of HIV-1 core is not well understood. We studied the internal structures by transmission electron microscopy. We modified the method for electron staining of ultrathin sections and processed electron microscopic photographs using a computer. We confirmed that a mature HIV-1 particle had two copies of RNA strands in a cone-shaped core. These two RNA strands formed a coiling structure and interwound each other, and were already present in the late budding stage.