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Combined Consumption of Beef‐Based Cooked Mince and Sucrose Stimulates Oxidative Stress, Cardiac Hypertrophy, and Colonic Outgrowth of Desulfovibrionaceae in Rats

Author:
Van Hecke, Thomas, De Vrieze, Jo, Boon, Nico, De Vos, Winnok H., Vossen, Els, De Smet, Stefaan
Source:
Molecular nutrition & food research 2019 v.63 no.2 pp. e1800962
ISSN:
1613-4125
Subject:
C-reactive protein, Desulfovibrionaceae, Lactobacillus, beef, blood, blood lipids, chicken meat, chronic diseases, corn starch, dietary fat, dysbiosis, enzyme activity, epidemiological studies, fatty acid composition, glutathione, glutathione peroxidase, hypertrophy, inflammation, intestinal microorganisms, intestines, lard, lean meat, lipid peroxidation, liver, malondialdehyde, microbiome, nutrition risk assessment, oxidative stress, rats, red meat, stomach, sucrose
Abstract:
SCOPE: High red meat and sucrose consumption increases the epidemiological risk for chronic diseases. Mechanistic hypotheses include alterations in oxidative status, gut microbiome, fat deposition, and low‐grade inflammation. METHODS AND RESULTS: For 2 weeks, 40 rats consumed a diet high in white or red meat (chicken‐based or beef‐based cooked mince, respectively), and containing corn starch or sucrose in a 2 × 2 factorial design. Lard was mixed with lean chicken or beef to obtain comparable dietary fatty acid profiles. Beef (vs chicken)‐fed rats had higher lipid oxidation products (malondialdehyde, 4‐hydroxy‐2‐nonenal, and hexanal) in stomach content and blood, and lower blood glutathione. Sucrose (vs corn starch)‐fed rats showed increased blood lipid oxidation products and glutathione peroxidase activity, higher liver weight and malondialdehyde concentrations, and mesenterial and retroperitoneal fat accumulation. Beef–sucrose‐fed rats had increased cardiac weight, suggesting pathophysiological effects on the cardiovascular system. The colonic microbiome of beef–sucrose‐fed rats showed an outgrowth of the sulfate‐reducing family of the Desulfovibrionaceae, and lower abundance of the Lactobacillus genus, indicating intestinal dysbiosis. Blood C‐reactive protein, a marker for inflammation, was not different among groups. CONCLUSIONS: Consumption of a cooked beef‐based meat product with sucrose increased oxidative stress parameters and promoted cardiac hypertrophy and intestinal dysbiosis.
Agid:
6279390