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First detection and genetic analysis of fox‐origin porcine circovirus type 2

Song, Tao, Zhang, Shoucong, Hao, Jianxiang, Xin, Shuyang, Hui, Weirong, Tang, Menghu, Li, Wenao, Tian, Rui, Liu, Xuanfu, Rui, Ping, Ren, Hai, Wang, Chunfang, Fu, Qiyuan, Ma, Zengjun
Transboundary and emerging diseases 2019 v.66 no.1 pp. 1-6
Porcine circovirus, Porcine circovirus-2, emerging diseases, foxes, fur, genetic analysis, genome, genotype, nucleotide sequences, phylogeny
Porcine circovirus type 2 (PCV2) is a causative agent of porcine circovirus‐associated disease (PCVAD), which is a serious problem in the swine industry worldwide. In recent years, nonporcine‐origin PCV2 has attracted more and more attention of the researchers. This study reported on the first identification of PCV2 in farmed foxes with reproductive failure. Three fox‐origin PCV2 strains were successfully isolated, sequenced, and designated as FoxHB1, FoxHB2, and FoxHB3 respectively. Pairwise‐sequence comparisons of the complete genomes revealed that three fox‐origin PCV2 strains had nucleotide identities varied from 91.9% to 99.7% with representative strains of PCV2 different genotypes. Meanwhile, phylogenetic analysis based on complete genomes of 44 PCV2 strains indicated that the fox‐origin PCV2 strains belonged to Chinese epidemic genotypes PCV2b and PCV2d. These results provided the first supported evidence that PCV2 could infect foxes, implying that the cross‐species transmission of PCV2 would be a big threat to Chinese fur animal‐bearing industry.