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Glycoreplica peptides to investigate molecular mechanisms of immune-mediated physiological versus pathological conditions

Mazzoleni, Antonio, Mallet, Jean-Maurice, Rovero, Paolo, Papini, Anna Maria
Archives of biochemistry and biophysics 2019 v.663 pp. 44-53
antibodies, autoimmune diseases, autoimmunity, cross reaction, diagnostic techniques, glycoconjugates, moieties, molecular mimicry, oligosaccharides, pathogens, peptides, polysaccharides, therapeutics
Investigation of the role of saccharides and glycoconjugates in mechanisms of immune-mediated physiological and pathological conditions is a hot topic. In fact, in many autoimmune diseases cross-reactivity between sugar moieties exposed on exogenous pathogens and self-molecules has long been hinted. Several peptides have been reported as mimetics of glycans specifically interacting with sugar-binding antibodies. The seek for these glycoreplica peptides is instrumental in characterizing antigen mimicry pathways and their involvement in triggering autoimmunity. Therefore, peptides mimicking glycan-protein interactions are valuable molecular tools to overcome the difficulties of oligosaccharide preparations. The clinical impact of peptide-based probes for autoimmune diseases diagnosis and follow-up is emerging only recently as just the tip of the iceberg of an overlooked potential. Here we provide a brief overview of the relevance of the structural and functional aspects of peptide probes and their mimicry effect in autoimmunity mechanisms for promising applications in diagnostics and therapeutics.