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An Allosteric Switch Primes Sequence-Specific DNA Recognition

Author:
Walker, Matthew J., Varani, Gabriele
Source:
Cell 2019 v.176 no.1-2 pp. 4-6
ISSN:
0092-8674
Subject:
DNA, DNA-binding proteins, binding capacity, enzymes
Abstract:
Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.
Agid:
6282814