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An Allosteric Switch Primes Sequence-Specific DNA Recognition
- Walker, Matthew J., Varani, Gabriele
- Cell 2019 v.176 no.1-2 pp. 4-6
- DNA, DNA-binding proteins, binding capacity, enzymes
- Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.