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The acaricidal activity and mechanism of eugenol on Psoroptes cuniculi
- Ma, Wuren, Fan, Yunpeng, Liu, Zengyuan, Hao, Yuanjie, Mou, Yuan, Liu, Yingqiu, Zhang, Weimin, Song, Xiaoping
- Veterinary parasitology 2019 v.266 pp. 56-62
- Psoroptes cuniculi, acaricidal properties, acaricides, eugenol, gene expression, glutathione transferase, mechanism of action, messenger RNA, mites, peroxisome proliferator-activated receptors, signal transduction, thioredoxins, tumor necrosis factors
- In this study, the acaricidal effect of eugenol was measured and its mechanism of action investigated. The results showed that eugenol possessed the effect of killing Psoroptes cuniculi, and could regulate the mRNA expression of glutathione S-transferase (GST), catechinic acid (Ca) and thioredoxin (Trx). PPAR, NF-kappa B, TNF, Rap 1 and Ras signaling pathways might be the main pathways that involved into the process of killing mites. These findings suggested that eugenol could be developed into a new kind of acaricide, and further expand current knowledge on the mechanisms of eugenol for killing Psoroptes cuniculi of eugenol.