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Hypolipidemic phenanthraquinone derivatives from Heleocharis dulcis
- Wei, Rong-Rui, Ma, Qin-Ge, Sang, Zhi-Pei
- Biochemical systematics and ecology 2019 v.83 pp. 17-21
- Eleocharis, chemotaxonomy, human cell lines, nuclear magnetic resonance spectroscopy, quinones, triacylglycerols
- Three new phenanthraquinones (1–3), together with seven known phenanthraquinone derivatives (4–10) were isolated from Heleocharis dulcis for the first time. Their structures were established on extensive NMR, MS, UV, IR experiments in conjunction with their references. Compounds (1–10) were evaluated for their hypolipidemic activities for the first time. Compounds 1, 3, 7, and 9 (10 μM) exhibited significant hypolipidemic activities by measuring the triglyceride content in HepG2 cells with simvastatin as positive control. The chemotaxonomic significance of compounds (1–10) was also discussed.