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Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats

Author:
Linderborg, Kaisa M., Kulkarni, Amruta, Zhao, Ai, Zhang, Jian, Kallio, Heikki, Magnusson, Johann D., Haraldsson, Gudmundur G., Zhang, Yumei, Yang, Baoru
Source:
Food chemistry 2019 v.283 pp. 381-389
ISSN:
0308-8146
Subject:
bioavailability, docosahexaenoic acid, enantiomers, fatty acid composition, feces, phospholipids, rats, secretion, stearic acid, triacylglycerols
Abstract:
Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.
Agid:
6285074