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Long-lasting and controlled antioxidant property of immobilized gold nanoparticles for intelligent packaging

Author:
Beurton, J., Clarot, I., Stein, J., Creusot, B., Marcic, C., Marchioni, E., Boudier, A.
Source:
Colloids and surfaces 2019 v.176 pp. 439-448
ISSN:
0927-7765
Subject:
2,2-diphenyl-1-picrylhydrazyl, acetylcysteine, antioxidant activity, biochemical compounds, colloids, free radicals, glass, half life, nanogold, oxidative stress, packaging, thiols
Abstract:
The development of new packaging able to preserve sensitive biomolecules against oxidative stress is an important field. Several studies refer to antioxidant properties carried out by colloidal gold nanoparticles (AuNP). Herein, the purpose was to check whether this property is preserved when AuNP are immobilized on a glass support. After nanostructured film preparation, the physicochemical characterization proved that AuNP were well-individualized in the films with a high density of immobilization. Two radicals: ABTS•+ and DPPH• were used to investigate their antioxidant capacity. The results showed that immobilized AuNP had a preserved antioxidant capacity characterized by a different kinetic: more controlled and more prolonged but with the same efficiency (vs the same quantity of colloidal AuNP). The AuNP films demonstrated a capacity to prevent from degradation a molecule containing a thiol function. A 10-fold increase of N-acetylcysteine half-life was measured using the immobilized AuNP, highlighting the interest of the developed and adaptable support.
Agid:
6285610