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The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats

Huang, Yun, Yao, Ping, Leung, Ka Wing, Wang, Huaiyou, Kong, Xiang Peng, Dong, Tina Ting Xia, Chen, Yicun, Qin, Qi-Wei, Tsim, Karl Wah Keung
Phytomedicine 2018 pp. 152815
Astragalus, Nelumbo, Oriental traditional medicine, Panax, alanine, blood, choline, creatine, cyclic AMP, drug therapy, energy, fever, herbal medicines, herbs, histidine, lactic acid, leucine, lipids, medicinal plants, metabolites, myo-inositol, rats, tyrosine, China
According to traditional Chinese medicine (TCM) theory, the herbal property is the most important guiding principle of ancient medication in China. The classification of warm- and cold-stimulating TCM is defined mainly based on the effects of herbs in regulating body temperature; however, the underlying mechanism of such distinction has not been fully identified.Here, four commonly used spleen-meridian herbs, Ginseng Radix and Astragali Radix as typical warm-stimulating herbs, and Nelumbinis Semen and Coicis Semen as typical cold-stimulating herbs, were selected to test their effects in regulating body temperature, as well as its triggered thermo-regulatory factors and energy related metabolites, in yeast-induced fever rats.The intake of Astragali Radix increased body temperature in yeast-induced fever rats; while Coicis Semen showed cooling effects in such rats. In parallel, the levels of cAMP, PGE2 and thermo-related metabolites, including choline, creatine, alanine, lactate and leucine, in the blood of yeast-induced rats were increased significantly by the intake of Astragali Radix. Oppositely, the cold-stimulating herbs, Nelumbinis Semen and Coicis Semen, showed cooling effects by increasing certain metabolites, e.g. histidine, tyrosine, lipid, myo-inositol, as well as AVP level.Here, we compared different effects of warm and cooling spleen-meridian herbs in the regulation of body temperature. By providing an intuitive comparison of thermo-regulatory factors and related metabolites after intake of selected herbs, the mechanism behind the warm and cooling effects of specific herbs were revealed.