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para-Aminobenzoate Synthesis versus Salvage in Malaria Parasites
- Mather, Michael W., Ke, Hangjun
- Trends in parasitology 2019 v.35 no.3 pp. 176-178
- antimalarials, diet, enzymes, folic acid, malaria, mice, models, parasites
- Enzymes of the folate de novo synthesis pathway in malaria parasites are proven antimalarial drug targets. A key precursor for folate synthesis is para-aminobenzoate (pABA). In a recent study  (Cell Rep. 2019;26:356–363 e4), the contributions of pABA synthesis versus salvage were re-evaluated in a rodent malaria model with knockout parasites grown in mice fed with various diets. The results imply that malaria parasites can either synthesize or salvage pABA to meet the demand for folates.