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para-Aminobenzoate Synthesis versus Salvage in Malaria Parasites

Author:
Mather, Michael W., Ke, Hangjun
Source:
Trends in parasitology 2019 v.35 no.3 pp. 176-178
ISSN:
1471-4922
Subject:
antimalarials, diet, enzymes, folic acid, malaria, mice, models, parasites
Abstract:
Enzymes of the folate de novo synthesis pathway in malaria parasites are proven antimalarial drug targets. A key precursor for folate synthesis is para-aminobenzoate (pABA). In a recent study [1] (Cell Rep. 2019;26:356–363 e4), the contributions of pABA synthesis versus salvage were re-evaluated in a rodent malaria model with knockout parasites grown in mice fed with various diets. The results imply that malaria parasites can either synthesize or salvage pABA to meet the demand for folates.
Agid:
6286888