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Efficacy of probiotics to prevent and/or alleviate childhood rotavirus infections
- Yang, Yongheng, Pei, Jianan, Qin, Zelan, Wei, Lijuan
- Journal of functional foods 2019 v.52 pp. 90-99
- Rotavirus, childhood, diarrhea, fever, meta-analysis, odds ratio, probiotics, vomiting
- Probiotics have been recommended to prevent or alleviate childhood rotavirus infections. This study aimed to generate more reliable estimates of effects of probiotics on childhood rotavirus infection, by the use of a meta-analysis approach. The pooled odds ratio (95% CI) of incidence of rotavirus infections was 0.71 (0.45, 1.12) for effects of probiotics on preventing rotavirus infections, whereas pooled odds ratio of incidence of effective cases after treatment was 3.61 (2.72, 4.79) for effects of probiotics on treating rotavirus infections, compared with control. Pooled standardized mean differences (95% CI) of durations of diarrhea, fever, vomiting, course of disease and hospitalization, were −1.31 (−1.58, −1.05), −1.36 (−1.72, −0.99), −1.30 (−1.79, −0.80), −0.28 (−0.79, 0.23), and −1.18 (−1.76, −0.60), respectively, for effects of probiotic on treating rotavirus infections compared with control. Findings of this study added evidence to support recommendation of probiotics for preventing or treatment of childhood rotavirus infections.