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Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model

Zorzan, Maira, Collazuol, Daniela, Ribaudo, Giovanni, Ongaro, Alberto, Scaroni, Carla, Zagotto, Giuseppe, Armanini, Decio, Barollo, Susi, Galeotti, Fabio, Volpi, Nicola, Redaelli, Marco, Pezzani, Raffaele
Journal of functional foods 2019 v.54 pp. 92-97
Pistacia lentiscus, cytokines, enzyme activity, glycemic control, human cell lines, humans, mechanism of action, models, mucosa, permeability, small intestine, sucrose alpha-glucosidase, toxicity
Pistacia lentiscus L. (PL) is an evergreen shrub from which it is derived a precious aromatic resin called mastic gum or mastic. This extract possesses numerous proprieties, such as antimicrobial, anti-inflammatory, anticancer, etc. The aim of this study was to investigate the biological activities of a patented PL Chios mastic extract in a human small intestine mucosa model, the Caco-2 cells. PL Chios mastic extract showed no toxic effect in Caco-2 cells treated with lower concentrations (<100 μg/ml). Pro-inflammatory cytokines were not increased in Caco-2 cells and disaccharidase activity as well as sucrase–isomaltase expression were decreased at 50 μg/ml, suggesting a potential role in glycaemic control. Also paracellular permeability was reduced in Caco-2 cells and remarkably this extract induced a barrier effect useful in protecting against chemical or biological insults.