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Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model

Author:
Zorzan, Maira, Collazuol, Daniela, Ribaudo, Giovanni, Ongaro, Alberto, Scaroni, Carla, Zagotto, Giuseppe, Armanini, Decio, Barollo, Susi, Galeotti, Fabio, Volpi, Nicola, Redaelli, Marco, Pezzani, Raffaele
Source:
Journal of functional foods 2019 v.54 pp. 92-97
ISSN:
1756-4646
Subject:
Pistacia lentiscus, cytokines, enzyme activity, glycemic control, human cell lines, humans, mechanism of action, models, mucosa, permeability, small intestine, sucrose alpha-glucosidase, toxicity
Abstract:
Pistacia lentiscus L. (PL) is an evergreen shrub from which it is derived a precious aromatic resin called mastic gum or mastic. This extract possesses numerous proprieties, such as antimicrobial, anti-inflammatory, anticancer, etc. The aim of this study was to investigate the biological activities of a patented PL Chios mastic extract in a human small intestine mucosa model, the Caco-2 cells. PL Chios mastic extract showed no toxic effect in Caco-2 cells treated with lower concentrations (<100 μg/ml). Pro-inflammatory cytokines were not increased in Caco-2 cells and disaccharidase activity as well as sucrase–isomaltase expression were decreased at 50 μg/ml, suggesting a potential role in glycaemic control. Also paracellular permeability was reduced in Caco-2 cells and remarkably this extract induced a barrier effect useful in protecting against chemical or biological insults.