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Bovine α-lactalbumin hydrolysates (α-LAH) attenuate high-fat diet induced nonalcoholic fatty liver disease by modulating hepatic lipid metabolism in C57BL/6J mice

Gao, Jing, Song, Jiajia, Du, Min, Mao, Xueying
Journal of functional foods 2019 v.54 pp. 254-262
blood lipids, blood serum, body weight changes, cattle, cytokines, fatty liver, gene expression, gene expression regulation, high fat diet, hydrolysates, lactalbumin, lipid metabolism, liver, mice, oxidative stress, peroxisome proliferator-activated receptor alpha, peroxisome proliferator-activated receptor gamma, tissue weight
The effect of bovine α-lactalbumin hydrolysates (α-LAH) on attenuating high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) was investigated. C57BL/6J mice were fed with HFD for 8 weeks to mimic the clinical features of NAFLD, and then were fed with HFD and bovine α-LAH at different doses (100, 200 and 400 mg/kg b.w.) for another 12 weeks to investigate the beneficial effects of bovine α-LAH on NAFLD. Our data showed that bovine α-LAH markedly reversed the increase of body weight gain, tissue weight, serum lipids, liver injury markers, and serum pro-inflammatory cytokines induced by HFD in C57BL/6J mice. Bovine α-LAH supplementation also ameliorated fat accumulation and oxidative stress, down-regulated PPARγ associated gene expression, and up-regulated PPARα associated gene expression in the liver of mice fed HFD. These findings suggested that bovine α-LAH is effective in attenuating HFD induced NAFLD in C57BL/6J mice.