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Butenolides, triterpenoids and phenylethanoid glycosides from Plantago depressa
- Song, Xiu-Qing, Bao, Jie, Sun, Jia, Cheng, Zhi-Qiang, Zhang, Yuying, Yu, Jin-Hai, Jiang, Cheng-Shi, Zhang, Hua
- Phytochemistry letters 2019 v.30 pp. 21-25
- 2,2-diphenyl-1-picrylhydrazyl, Plantago, bioassays, glycosides, inhibitory concentration 50, nitric oxide, spectral analysis, triterpenoids
- Four new compounds, including two butenolides (1 and 2), an arborinane-type triterpenoid (3) and a phenylethanoid glycoside (4), along with the known triterpenoids (5–17) and phenylethanoid glycosides (18–29), were isolated from whole plants of Plantago depressa. The structures of the isolated compounds were elucidated by comprehensive spectroscopic analyses and were evaluated for their anti-inflammatory or antiradical activities. Our results underlined that, among compounds 1–17, only compound 16 inhibited lipopolysaccharide-induced NO production with an IC50 equal to 5.33 ± 0.51 μM. All phenylethanoid glycosides (4, 18–29) were evaluated for their antiradical activity with a DPPH radical scavenging bioassay and showed high to moderate effect (IC50 from 2.70 to 51.51 μM).