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Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines
- Curado, Natalia, Dewaele-Le Roi, Guillaume, Poty, Sophie, Lewis, Jason S., Contel, Maria
- Chemical communications 2019 v.55 no.10 pp. 1394-1397
- antineoplastic activity, breast neoplasms, cell lines, chemical bonding, chemical communication, chemical reactions, cytotoxicity, gold, in vitro studies, monoclonal antibodies, neoplasm cells
- We describe the preparation of gold(i)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab–gold conjugates were synthesized and fully characterized. These bioconjugates are significantly more cytotoxic (sub-micromolar range) to HER2-positive breast cancer cells than the gold complexes and Trastuzumab.