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Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729
- Chen, Senhua, Shen, Hongjie, Zhang, Panpan, Cheng, Hongwei, Dai, Xingliang, Liu, Lan
- Chemical communications 2019 v.55 no.10 pp. 1438-1441
- alkaloids, anti-infective agents, apoptosis, cell lines, chemical communication, chemical reactions, fungi, gene expression, gene expression regulation, glioma, moieties
- Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression.