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A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding

Author:
Nishimura, Shin-nosuke, Higashi, Nobuyuki, Koga, Tomoyuki
Source:
Chemical communications 2019 v.55 no.10 pp. 1498-1501
ISSN:
1364-548X
Subject:
chemical communication, chemical reactions, nanoparticles, polymers, temperature
Abstract:
A novel multiblock architecture composed of an alternating β-sheet forming oligopeptide and a thermo-responsive glycine-derived vinyl polymer was synthesized. The polymer exhibited lower critical solution temperature (LCST) behavior in water, unlike the behavior of a glycine-derived homopolymer, and formed nanoparticles through protein-mimicking folding driven by thermal cycle-induced β-sheet formation.
Agid:
6287774