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The non-competitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) tubers
- Benedict T. Green, Camila Goulart, Kevin D. Welch, James A. Pfister, Isabelle McCollum, Dale R. Gardner
- Toxicon 2015 v.108 pp. 11-14
- Cicuta, gamma-aminobutyric acid receptors, plant extracts, poisonous plants, polyacetylenes, toxicity, tubers
- Water hemlocks (Cicuta spp.) are acutely toxic members of the Umbellierae family; the toxicity is due to the presence of C17-polyacetylenes such as cicutoxin. There is only limited evidence of noncompetitive antagonism by C17-polyacetylenes at GABAA receptors. In this work with WSS-1 cells, we documented the noncompetitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) and modulated the actions of the extract with a pretreatment of 10 μM midazolam.