PubAg

Main content area

A novel sodium carbonate-catalyzed regioselective synthesis of pyrano[2,3-h]coumarins using a three-component reaction

Author:
Tanuraghaj, Hamideh Mohamadi, Farahi, Mahnaz
Source:
Tetrahedron letters 2019 v.60 no.7 pp. 557-559
ISSN:
0040-4039
Subject:
aldehydes, chemical reactions, chemical structure, coumarin, regioselectivity, sodium carbonate
Abstract:
In this work, a novel, convenient, and efficient approach to the synthesis of pyrano[2,3-h]coumarins has been reported based on the multicomponent reaction. The one-pot reaction between 5,7-dihydroxy-4-methylcoumarin, dialkyl acetylenedicarboxylate and aromatic aldehydes catalyzed by sodium carbonate lead to the formation of a novel class of pyrano[2,3-h]coumarin derivatives. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this protocol. This method allows access to a variety of pyrano[2,3-h]coumarins via using a broad substrate scope.
Agid:
6290054