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Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: A cross-sectional study

Khor, Ban-Hock, Sahathevan, Sharmela, Sualeheen, Ayesha, Ali, Mohammad Syafiq Md, Narayanan, Sreelakshmi Sankara, Chinna, Karuthan, Gafor, Abdul Halim Abdul, Goh, Bak-Leong, Ahmad, Ghazali, Morad, Zaki, Daud, Zulfitri Azuan Mat, Khosla, Pramod, Sundram, Kalyana, Karupaiah, Tilakavati
Nutrition 2019 v.63-64 pp. 14-21
biomarkers, cross-sectional studies, databases, dietary fat, erythrocytes, fat intake, fatty acid composition, fish, foods, hemodialysis, isomers, monounsaturated fatty acids, omega-3 fatty acids, omega-6 fatty acids, patients, polyunsaturated fatty acids, seafood consumption, triacylglycerols
The aims of this study were threefold:first, to assess the dietary fatty acid (FA) intake and blood FA status in Malaysian patients on hemodialysis (HD); second, to examine the association between dietary FA intakes and blood FA profiles in patients on HD; and third, to determine whether blood FAs could serve as a biomarker of dietary fat intake quality in these patients.Using 3 d of dietary records, FA intakes of 333 recruited patients were calculated using a food database built from laboratory analyses of commonly consumed Malaysian foods. Plasma triacylglycerol (TG) and erythrocyte FAs were determined by gas chromatography.High dietary saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) consumption trends were observed. Patients on HD also reported low dietary ω-3 and ω-6 polyunsaturated fatty acid (PUFA) consumptions and low levels of TG and erythrocyte FAs. TG and dietary FAs were significantly associated respective to total PUFA, total ω-6 PUFA, 18:2 ω-6, total ω-3 PUFA, 18:3 ω-3, 22:6 ω-3, and trans 18:2 isomers (P < 0.05). Contrarily, only dietary total ω-3 PUFA and 22:6 ω-3 were significantly associated with erythrocyte FAs (P < 0.01). The highest tertile of fish and shellfish consumption reflected a significantly higher proportion of TG 22:6 ω-3. Dietary SFAs were directly associated with TG and erythrocyte MUFA, whereas dietary PUFAs were not.TG and erythrocyte FAs serve as biomarkers of dietary PUFA intake in patients on HD. Elevation of circulating MUFA may be attributed to inadequate intake of PUFAs.