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CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

Author:
Cowling, Victoria H.
Source:
Trends in biochemical sciences 2019 v.44 no.3 pp. 183-185
ISSN:
0968-0004
Subject:
adenosine, messenger RNA, methylation, transcription (genetics), transferases, translation (genetics)
Abstract:
The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.
Agid:
6293101