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Identification and expression analysis of Fc receptor-like proteins in Japanese flounder (Paralichthys olivaceus)

Author:
Jirapongpairoj, Walissara, Hirono, Ikuo, Kondo, Hidehiro
Source:
Fish & shellfish immunology 2019 v.87 pp. 82-86
ISSN:
1050-4648
Subject:
Edwardsiella tarda, Paralichthys olivaceus, Streptococcus iniae, amino acids, fish, immunoglobulins, kidneys, messenger RNA, open reading frames, pathogens, receptors, shellfish, spleen
Abstract:
Fc receptors (FcRs) are specific to the Fc portion of immunoglobulin (Ig) molecules. Here, four Fc receptor-like proteins, JF-FcR-like protein 1-4, were identified in Japanese flounder. Their open reading frames encoded 358, 255, 519 and 441 amino acid residues, respectively. JF-FcR-like protein mRNAs were mainly detected in kidney and spleen of healthy fish. Injection of formalin-killed cells (FKCs) of Edwardsiella tarda significantly increased the spleen mRNA levels of JF-FcR-like protein 1 but not the other JF-FcR-like proteins. Injection of FKC of Streptococcus iniae did not significantly affect any of the JF-FcR-like protein mRNAs. These findings suggest that the FcR-like proteins have different involvements in pathogen responses.
Agid:
6293396