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The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson’s Disease

Author:
Donyo, Maya, Ashkenazi, Avraham
Source:
Molecular cell 2019 v.73 no.1 pp. 5-6
ISSN:
1097-2765
Subject:
Parkinson disease, feeds, neurons, polymers, protein aggregates, toxicity
Abstract:
Parkinson’s disease (PD) is characterized by protein aggregates of α-synuclein in neurons. In a recent issue of Science, Kam et al. (2018) revealed a feedforward loop in which α-synuclein increases the levels of poly(adenosine 5′-diphosphate-ribose) (PAR) that in turn causes α-synuclein aggregates to be more toxic. This study advances our understanding of PD pathology.
Agid:
6293571