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The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson’s Disease
- Donyo, Maya, Ashkenazi, Avraham
- Molecular cell 2019 v.73 no.1 pp. 5-6
- Parkinson disease, feeds, neurons, polymers, protein aggregates, toxicity
- Parkinson’s disease (PD) is characterized by protein aggregates of α-synuclein in neurons. In a recent issue of Science, Kam et al. (2018) revealed a feedforward loop in which α-synuclein increases the levels of poly(adenosine 5′-diphosphate-ribose) (PAR) that in turn causes α-synuclein aggregates to be more toxic. This study advances our understanding of PD pathology.