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Two unprecedented nor-iridal esters from Iris wattii Baker and their bioactivities

Ni, Gang, Li, Jia-Yuan, Yu, De-Quan
Phytochemistry letters 2019 v.31 pp. 43-46
alpha-glucosidase, bioactive properties, chromatography, esters, nuclear magnetic resonance spectroscopy, protein-tyrosine-phosphatase, spectral analysis, triterpenoids
Two unprecedented C16nor-iridal esters (1―2), named iriwattin A (1) and iriwattin B (2), along with one known iridal ester and two known iridal-type triterpenoids were isolated from Iris wattii Baker by comprehensive chromatographic methods. The structures of 1―2 were elucidated by interpretation of extensive spectroscopic analyses (1D and 2D NMR, ESI- and HRESI-MS). The two new compounds have interesting nor-iridal skeleton that are previously undescribed, and therefore constitute a new class of C16nor-iridal esters. Furthermore, compounds 1 and 2 were tested for their in vitro inhibitory activities against α-glucosidase and protein tyrosine phosphatase 1B (PTP1B). Compound 1 showed a certain degree of inhibitory effect on the PTP1B enzyme, with 52.0% inhibition.