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Scop3D: Online Visualization of Mutation Rates on Protein Structure
- Kreft, Lukasz, Turan, Demet, Hulstaert, Niels, Botzki, Alexander, Martens, Lennart, Vandermarliere, Elien
- Journal of proteome research 2018 v.18 no.2 pp. 765-769
- DNA, amino acid sequences, genomics, germplasm conservation, proteome, single nucleotide polymorphism
- Scop3D is a tool that automatically annotates protein structure with sequence conservation starting from a set of protein sequence variants. We present a complete upgrade and rewrite of Scop3D. We have included a DNA module that allows the analysis of single nucleotide polymorphisms in relation to the structural context of the protein. Scop3D therefore forms a bridge between genomics and protein structure. Moreover, Scop3D is now also available through an intuitive web-interface that makes the tool highly user-friendly.