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Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells

Author:
Bhattacharjee, Sankhajit, Jaiswal, Rishi Kumar, Yadava, Pramod Kumar
Source:
Journal of biosciences 2019 v.44 no.1 pp. 10
ISSN:
0250-5991
Subject:
DNA-directed RNA polymerase, Measles virus, RNA, antineoplastic agents, apoptosis, cell proliferation, children, developing countries, genome, genomics, human cell lines, measles, migratory behavior, mortality, neoplasm cells, nucleocapsid proteins, phosphoproteins, ribonucleoproteins, uterine cervical neoplasms, vaccines, virus replication, viruses
Abstract:
Measles virus is the causative agent of measles, a major cause of child mortality in developing countries. Two major proteins, coded by the viral genome, are nucleocapsid protein (N) and phosphoprotein (P). The N protein protects the viral genomic RNA and forms ribonucleoprotein complex (RNP) together with P protein. MeV-P protein recruits the large protein (L), i.e. viral RNA-depended RNA polymerase (RdRp), to ensure viral replication in host cell. Apoptogenic properties of N protein of Edmonston vaccine strain have been established in our lab previously. We investigated the role of MeV-P protein of Edmonston vaccine strain as modulator of apoptosis in cervical cancer cell line (HeLa) and found that MeV-P protein is anti-apoptotic and enhances cell proliferation. Measles virus is considered to be innately oncotropic virus. However, the anti-apoptotic property of MeV-P protein raises important concerns while adopting this virus as an anti-cancer therapeutic tool.
Agid:
6296945