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Bioactive constituents from marine-derived Streptomyces sp. NB-A13

Author:
Wang, Qian-qian, Zhou, Biao, Ji, Yuan-yuan, Zhang, Hao-jian, Ma, Zhong-jun, Shen, Li, Ding, Wan-jing
Source:
Phytochemistry letters 2019
ISSN:
1874-3900
Subject:
Streptomyces, anthracyclines, circular dichroism spectroscopy, cytotoxicity, density functional theory, inhibitory concentration 50, neoplasm cells, nuclear magnetic resonance spectroscopy, prostatic neoplasms, spectral analysis
Abstract:
Six new anthracyclines (1-6) were obtained by the investigation of the solid fermented extract of a marine-derived Streptomyces sp. NB-A13. The structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, HRESIMS, UV and IR. The absolute configurations of compounds 1-5 were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. Among the isolates, four compounds (2, 3, 5 and 6) showed moderate cytotoxic activity against PC3 cells (prostate cancer cells) with IC50 values of 7.0 ± 0.3 µM, 0.92 ± 0.05 µM, 2.1 ± 0.7 µM and 9.8 ± 0.7 µM, respectively.
Agid:
6298255