PubAg

Main content area

Sesquiterpene and monoterpene derivatives from the soil-derived fungus Trichoderma reesei PSU-SPSF013

Author:
Rukachaisirikul, Vatcharin, Chinpha, Supaporn, Phongpaichit, Souwalak, Saikhwan, Nanthawath, Sakayaroj, Jariya, Preedanon, Sita
Source:
Phytochemistry letters 2019 v.30 pp. 124-129
ISSN:
1874-3900
Subject:
Cryptococcus neoformans, Trichoderma reesei, adenosine, alcohols, antifungal properties, fungi, minimum inhibitory concentration, moieties, monoterpenoids, sesquiterpenoids, spectral analysis, uridine
Abstract:
Three new sesquiterpenes (1-3) and one new monoterpene (4) were isolated from the soil-derived fungus Trichoderma reesei PSU-SPSF013 along with five known compounds including hydroheptelidic acid (5), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (6), adenosine (7), uridine (8) and tyrosol (9). Their structures were elucidated by spectroscopic analyses. The absolute configuration of the secondary alcohol moiety in 2 was assigned using Mosher’s method whereas that of 1, 3 and 4 was established by comparison of their specific rotations with those of structurally related compounds. Compounds 3-5 displayed interesting antifungal activity against Cryptococcus neoformans ATCC90113 with the respective MIC values of 8, 8 and 4 μg/mL. Moreover, only 3 was active against C. neoformans ATCC90112 with the MIC value of 32 μg/mL. Interestingly, 4 and 5 were noncytotoxic towards noncancerous Vero cells.
Agid:
6298256