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Evaluation of the respiratory elimination kinetics of selenate and Se-methylselenocysteine after oral administration in lambs

T.Z. Davis, B.L. Stegelmeier, B.T. Green, K.D. Welch, J.O. Hall
Research in veterinary science 2013 v.95 no.3 pp. 1163-1168
air, dose response, forage, lambs, methylselenocysteine, oral administration, pharmacokinetics, selenates, selenium, selenomethionine, sodium, sodium selenite
Sheep can be acutely poisoned by selenium (Se) accumulating forages which often contain selenate or Se-methylselenocysteine as their predominant forms. Excess Se can be eliminated via respiration. Sheep were given a single oral dose of 0, 1, 2, 3, 4, or 6mg Se/kg BW as sodium selenate and Se-methylselenocysteine or 6mg Se/kg BW as sodium selenite or selenomethionine. Expired air samples were collected and analyzed for Se. The Se concentration of the expired air reflected a dose-dependent increase at individual time points for both Se-methylselenocysteine and sodium selenate, however, Se content was greater and eliminated more rapidly from sheep receiving Se-methylselenocysteine. The mean Se concentration in respired air from sheep administered 6mg Se/kg BW of different selenocompounds was greatest in sheep dosed Se-methylselenocysteine>selenomethionine>sodium selenate>sodium selenite. The Se concentration in respired air of acutely poisoned sheep is significantly different for different chemical forms of Se.