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Evaluation of the respiratory elimination kinetics of selenate and Se-methylselenocysteine after oral administration in lambs

Author:
T.Z. Davis, B.L. Stegelmeier, B.T. Green, K.D. Welch, J.O. Hall
Source:
Research in veterinary science 2013 v.95 no.3 pp. 1163-1168
ISSN:
0034-5288
Subject:
air, dose response, forage, lambs, methylselenocysteine, oral administration, pharmacokinetics, selenates, selenium, selenomethionine, sodium, sodium selenite
Abstract:
Sheep can be acutely poisoned by selenium (Se) accumulating forages which often contain selenate or Se-methylselenocysteine as their predominant forms. Excess Se can be eliminated via respiration. Sheep were given a single oral dose of 0, 1, 2, 3, 4, or 6mg Se/kg BW as sodium selenate and Se-methylselenocysteine or 6mg Se/kg BW as sodium selenite or selenomethionine. Expired air samples were collected and analyzed for Se. The Se concentration of the expired air reflected a dose-dependent increase at individual time points for both Se-methylselenocysteine and sodium selenate, however, Se content was greater and eliminated more rapidly from sheep receiving Se-methylselenocysteine. The mean Se concentration in respired air from sheep administered 6mg Se/kg BW of different selenocompounds was greatest in sheep dosed Se-methylselenocysteine>selenomethionine>sodium selenate>sodium selenite. The Se concentration in respired air of acutely poisoned sheep is significantly different for different chemical forms of Se.
Agid:
62993
Handle:
10113/62993